Avatar.

The number 1 position in the highest-grossing Hollywood movies of all time belongs to Avatar. It was released on December 18, 2009 and grossed $2.782 billion. The director of the movie is James Cameron.  It received universal critical acclaim and was nominated for 9 Oscar Awards. A sequel is announced to be released in 2015. Main cast includes Sam Worthington, Stephen Lang, Sigourney Weaver, Michelle Rodriguez, Zoe Saldana and Giovanni Ribisi.